CELL SIGNALING AND
MOLECULAR PHARMACOLOGY LAB
THE KANG LAB
SELECTED PAPERS
Kang, Hye Jin*; Krumm, Brian E.*; Tassou, Adrien*; Geron, Matan*; et al., Structure-guided design of a peripherally-restricted chemogenetic system, Cell 187, 26. (2024) (*equally contributed). https://doi.org/10.1016/j.cell.2024.11.001
Kang, Hye Jin#; Minamimoto, Takafumi; Wess, Jürgen; Roth, Bryan L#. Chemogenetics for cell-type specific modulation of signaling and neuronal activity, Nature Reviews Methods Primers 3, 93(2023) (# corresponding author). https://doi.org/10.1038/s43586-023-00276-1
Yang, Yang*, Kang, Hye Jin*, Gao, R.*, Wang, J., Han, G.W., DiBerto, J.F., Wu, L., Tong, J., Qu, L., Wu, Y., et al. Structural insights into the human niacin receptor HCA2-Gi signalling complex. Nature Communications 14, 1692. (2023) (*equally contributed). https://doi.org/10.1038/s41467-023-37177-6
Cao, Can*; Kang, Hye Jin* et al, Structure, function and pharmacology of human itch GPCRs. Nature 600, 170 (2021) (*equally contributed). https://doi.org/10.1038/s41586-021-04126-6
Stein, Reed M*; Kang, Hye Jin* et al, Virtual discovery of melatonin receptor ligands to modulate circadian rhythms. Nature 579, 609–614 (2020). (* equally contributed). https://doi.org/10.1038/s41586-020-2027-0
FULL LIST OF PUBLICATIONS
Yun Yeong Cho†, Soyeon Kim†, Pankyung Kim, Min Jeong Jo, Song-E Park, Yiju Choi, Su Myung Jung*, Hye Jin Kang*
(† equally contributed, * corresponding authors). https://doi.org/10.3390/biom15020291
Hye Jin Kang ∙ Brian E. Krumm ∙ Adrien Tassou ∙ Matan Geron∙ Jeffrey F. DiBerto ∙ Nicholas J. Kapolka ∙ Ryan H. Gumpper ∙ Kensuke Sakamoto ∙ D. Dewran Kocak ∙ Reid H.J. Olsen ∙ Xi-Ping Huang ∙ Shicheng Zhang ∙ Karen L. Huang ∙ Saheem A. Zaidi∙ My V.T. Nguyen ∙ Min Jeong Jo ∙ Vsevolod Katritch ∙ Jonathan F. Fay ∙ Grégory Scherrer gregory_scherrer ∙ Bryan L. Roth. https://doi.org/10.1016/j.cell.2024.11.001
Chemogenetics for cell-type-specific modulation of signalling and neuronal activity.
Nature Reviews Methods Primers (2023)
Hye Jin Kang#, Takafumi Minamimoto, Jürgen Wess, Bryan L Roth# (#corresponding author).
Docking for EP4R antagonists active against inflammatory pain.
Nature Communications (2023)
Stefan Gahbauer, Chelsea DeLeon, Joao M. Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan, Xi-Ping Huang, Christian B. Billesbølle, Yongfeng Liu, Tao Che, Ishan Deshpande, Madison Jewell, Elissa A. Fink, Ivan S. Kondratov, Yurii S. Moroz, John J. Irwin, Allan I. Basbaum, Bryan L. Roth & Brian K. Shoichet. https://doi.org/10.1038/s41467-023-43506-6
Yang Yang*, Hye Jin Kang*, Ruogu Gao*, Jingjing Wang, Gye Won Han, Jeffrey F DiBerto, Lijie Wu, Jiahui Tong, Lu Qu, Yiran Wu, Ryan Pileski, Xuemei Li, Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin, Quan Wang, Raymond C Stevens, Wei Peng, Bryan L Roth, Zihe Rao, Zhi-Jie Liu (*equally contributed). https://doi.org/10.1038/s41467-023-37177-6
Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Biochemistry (2023)
Brian E Krumm, Jeffrey F DiBerto, Reid HJ Olsen, Hye Jin Kang, Samuel T Slocum, Shicheng Zhang, Ryan T Strachan, Lauren M Slosky, Anthony B Pinkerton, Lawrence S Barak, Marc G Caron, Terry Kenakin, Bryan L Roth. https://doi.org/10.1021/acs.biochem.3c00029
Jordi Bonaventura, Juan L Gomez, Meghan L Carlton, Sherry Lam, Marta Sanchez-Soto, Patrick J Morris, Ruin Moaddel, Hye Jin Kang, Panos Zanos, Todd D Gould, Craig J Thomas, David R Sibley, Carlos A Zarate Jr, Michael Michaelides. https://doi.org/10.1038/s41380-022-01673-w
Gengyang Yuan, Maeva Dhaynaut, Nicolas J. Guehl, Sepideh Afshar, Dalena Huynh, Sung-Hyun Moon, Suhasini M. Iyengar, Manish Kumar Jain, Julie E. Pickett, Hye Jin Kang, Mary Jo Ondrechen, Georges El Fakhri, Marc D. Normandin, and Anna-Liisa Brownell. https://doi.org/10.1021/acs.jmedchem.2c00593
Design and discovery of a high affinity, selective and β-arrestin biased 5-HT7 receptor agonist.
Medicinal Chemistry Research (2022)
Onyameh, E.K., Ofori, E., Bricker, B.A., Gonela, U.M., Eyunni, S.V.K., Kang, Hye Jin, Voshavar, C., and Ablordeppey, S.Y. https://doi.org/10.1007/s00044-021-02797-4
Synthesis and Characterization of 5-(2-Fluoro-4-[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2.
Journal of Medicinal Chemistry (2022)
Gengyang Yuan; Maeva Dhaynaut; Yu Lan; Nicolas J. Guehl; Dalena Huynh; Suhasini M. Iyengar; Sepideh Afsha; Manish Kumar Jain; Julie E. Pickett; Hye Jin Kang; Hao Wang ; Sung-Hyun Moon; Mary Jo Ondrechen; Changning Wang; Timothy M. Shoup; Georges El Fakhri; Marc D. Normandin, and Anna-Liisa Brownell. https://doi.org/10.1021/acs.jmedchem.1c02004
A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects
Neuropharmacology (2021)
Pryce, K.D.*, Kang, Hye Jin* , Sakloth, F.*, Liu, Y., Khan, S., Toth, K., Kapoor, A., Nicolais, A., Che, T., Qin, L., et al. (*equally contributed). https://doi.org/10.1016/j.neuropharm.2021.108673
Cao, Can*; Kang, Hye Jin*; Singh, Isha ;Chen, He; Zhang, Chengwei ; Ye, Wenlei; Hayes, Byron; Liu, Jing ; Gumpper, Ryan; Bender, Brian; Slocum, Samuel; Krumm, Brian, Lansu, Katherine; McCorvy, John; Kroeze, Wesley; English, Justin; DiBerto, Jeffrey; Olsen, Reid; Huang, Xi-Ping; Zhang, Shicheng; Liu, Yongfeng ; Kim, Kuglae; Karpiak, Joel ; Jan, Lily; Abraham, Soman; Jin, Jian ; Shoichet, Brian; Fay, Jonathan; Roth, Bryan L. (*equally contributed).
Synthesis and Characterization of [18F]JNJ-46356479 as the First 18F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2.
Molecular Imaging and Biology (2021)
Yuan, G., Guehl, N.J., Zheng, B., Qu, X., Moon, S.-H., Dhaynaut, M., Shoup, T.M., Afshar, S., Kang, Hye Jin, Zhang, Z., et al.
Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2.
Journal of Medicinal Chemistry (2020)
Yuan, G., Qu, X., Zheng, B., Neelamegam, R., Afshar, S., Iyengar, S., Pan, C., Wang, J., Kang, Hye Jin, Ondrechen, M.J., et al.
Reed M Stein*, Hye Jin Kang*, John D McCorvy*, Grant C Glatfelter*, Anthony J Jones, Tao Che, Samuel Slocum, Xi-Ping Huang, Olena Savych, Yurii S Moroz, Benjamin Stauch, Linda C Johansson, Vadim Cherezov, Terry Kenakin, John J Irwin, Brian K Shoichet, Bryan L Roth, Margarita L Dubocovich (*equally contributed). https://doi.org/10.1038/s41586-020-2027-0
Synthesis and evaluation of a F-18 labeled tricyclic thiazolopyrazole derivative for imaging of metabotropic glutamate receptor 4 (mGluR4).
Journal of Nuclear Medicine (2020)
Wang, Junfeng; Shoup, Timothy; Qu, Xiying; Kang, Hye Jin; Fakhri, Georges El; Zhang, Zhaoda; Brownell, Anna-Liisa.
Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.
Nature Communications (2019)
McCarroll, Matthew N; Gendelev, Leo; Kinser, Reid; Taylor, Jack; Bruni, Giancarlo; Myers-Turnbull, Douglas; Helsell, Cole; Carbajal, Amanda; Rinaldi, Capria; Kang, Hye Jin; Gong, Jung Ho; Sello, Jason K; Tomita, Susumu; Peterson, Randall T; Keiser, Michael J; Kokel, David. https://doi.org/10.1038/s41467-019-11936-w
Evaluation of SYA16263 as a new potential antipsychotic agent without catalepsy.
Pharmacology Biochemistry and Behavior (2019)
Bricker, Barbara A; Peprah, Kwame; Kang, Hye Jin; Ablordeppey, SY. https://doi.org/10.1016/j.pbb.2019.02.003
Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4.
Bioorganic & Medicinal Chemistry (2018)
Gates, Christina; Backos, Donald S; Reigan, Philip; Kang, Hye Jin; Koerner, Chris; Mirzaei, Joseph; Natale, NR.
Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.
The FASEB Journal. (2017)
Le Gonidec, Sophie; Chaves-Almagro, Carline; Bai, Yushi; Kang, Hye Jin; Smith, Allyson; Wanecq, Estelle; Huang, Xi-Ping; Prats, H; Knibiehler, Bernard; Roth, Bryan L; Barak, L.S.; Caron, M.G.; Valet, P.; Audigier, Y; and Masri, Bernard.
Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2.
ACS Chemical Neuroscience (2017)
Zhang, Xiaofei; Kumata, Katsushi; Yamasaki, Tomoteru; Cheng, Ran; Hatori, Akiko; Ma, Longle; Zhang, Yiding; Xie, Lin; Wang, Lu; Kang, Hye Jin; Sheffler, Douglas J.; Cosford, Nicholas D. P.;Zhang, Ming-Rong; Liang, Steven H.
Effects of Ketamine and Ketamine Metabolites on Evoked Striatal Dopamine Release, Dopamine Receptors, and Monoamine Transporters.
The Journal of Pharmacology and Experimental Therapeutics (2016)
Can, Adem; Zanos, Panos; Moaddel, Ruin; Kang, Hye Jin; Dossou, Katinia SS; Wainer, Irving W; Cheer, Joseph F; Frost, Douglas O; Huang, Xi-Ping; Gould, Todd D. https://doi.org/10.1124/jpet.116.235838
Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.
Bioorganic & Medicinal Chemistry (2016).
Etukala, Jagan R; Zhu, Xue Y; Eyunni, Suresh VK; Onyameh, Edem K; Ofori, Edward; Bricker, Barbara A; Kang, Hye Jin; Huang, Xi-Ping; Roth, Bryan L; Ablordeppey, Seth Y. https://doi.org/10.1016/j.bmc.2016.06.011
Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.
Bioorganic & Medicinal Chemistry (2016)
Ofori, Edward; Zhu, Xue Y; Etukala, Jagan R; Peprah, Kwakye; Jordan, Kamanski R; Adkins, Adia A; Bricker, Barbara A; Kang, Hye Jin; Huang, Xi-Ping; Roth, Bryan L. https://doi.org/10.1016/j.bmc.2016.05.053
Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability.
Bioorganic & Medicinal Chemistry Letters (2015)
Zhaoda Zhang, Kun-Eek Kil, Pekka Poutiainen, Ji-Kyung Choi, Hye Jin Kang, Xi-Ping Huang, Bryan L Roth, Anna-Liisa Brownell. https://doi.org/10.1016/j.bmcl.2015.07.031
Determinants of Endogenous Ligand Specificity Divergence among Metabotropic Glutamate Receptors.
Journal of Biological Chemistry (2015)
Kang, Hye Jin; Wilkins, Angela D; Lichtarge, Olivier; Wensel, Theodore G. https://doi.org/10.1074/jbc.M114.622233
Selectivity and Evolutionary Divergence of Metabotropic Glutamate Receptors for Endogenous Ligands and G Proteins Coupled to Phospholipase C or TRP Channels
Journal of Biological Chemistry (2014)
Kang, Hye Jin; Menlove, Kit; Ma, Jianpeng; Wilkins, Angela; Lichtarge, Olivier; Wensel, Theodore G.